Abstract
A series of nonsteroidal human androgen receptor (hAR) antagonists based on 8-substituted 1,2-dihydro- and 1,2,3,4-tetrahydro-2,2-dimethyl-6-trifluoromethylpyrido[3,2-g]quin olines was synthesized. Compounds in this series were tested for the ability to bind to hAR and inhibit hAR-dependent transcription in a mammalian cellular background.
MeSH terms
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Androgen Antagonists / chemical synthesis*
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Androgen Antagonists / pharmacology
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Androgen Receptor Antagonists*
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Androgens / metabolism
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Animals
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COS Cells
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Humans
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Pyridones / chemical synthesis*
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Pyridones / chemistry*
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Pyridones / pharmacology
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Quinolines / chemical synthesis*
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Quinolines / pharmacology
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Transcription, Genetic / drug effects
Substances
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Androgen Antagonists
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Androgen Receptor Antagonists
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Androgens
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Pyridones
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Quinolines